Read our article and learn more on medlineplus: therapeutic drug levels. Other articles where therapeutic index is discussed: drug: dose-response relationship: this relationship, known as the therapeutic index, is defined as the ratio ld50:ed50. A ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective the larger the therapeutic index (ti), the safer the drug is.
These example sentences are selected automatically from various online news sources to reflect current usage of the word 'therapeutic index' views expressed in the examples do not represent the opinion of merriam-webster or its editors send us feedback . 872 vol 2, no 24 november 2002 abstract the therapeutic index of a histamine-1 (h1)- antihistamine is the benefit-to-risk ratio of the medication and defines the range of doses and. Therapeutic index is an “imaginary” ratio it is defined as the dose /or more accurately concentration which is toxic (or the maximum tolerated dose) to the concentration which produces a therapeutically beneficial effect. Therapeutic index equation the therapeutic index of a drug is the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response in a population of individuals.
According to the us food and drug administration (fda), a drug with a narrow therapeutic range (nti) is one with a narrow range between the drug's risks and its benefits the nti is also known a narrow therapeutic index or critical dose drug. Therapeutic drug monitoring some drugs have a narrow therapeutic index, which means that there is only a small difference between the minimum effective concentrations and the minimum toxic concentrations in the blood. Physiology lithium physiology has been studied extensively for almost 50 yr because of its use in treating manic-depressive illness lithium can substitute for sodium or potassium on several transport proteins that normally transport sodium or potassium, thus providing a pathway for lithium entry into cells.
E2 j clin exp dent 20102(1):e1-5 dabigatran and rivaroxaban in dentistry introduction oral anticoagulants are a group of drugs used to treat. This article is within the scope of wikiproject medicine, which recommends that medicine-related articles follow the manual of style for medicine-related articles and that biomedical information in any article use high-quality medical sources. •rationalandoptimaltherapy witha drugdepend upon‐ 1choiceofasuitabledrug,and 2balancebetween thetherapeutic andthetoxic‐ effects •both, the therapeutic and the toxic effects, depend upon. Clinical therapeutic index definition from the pharmacology and experimental therapeutics department glossary at boston university. The therapeutic index of a drug is the ratio of the toxic to the therapeutic dose drugs with a low therapeutic index may only require a small increase in dose to produce toxic effects.
An index's value may be weighted for example, securities with higher prices or greater market capitalization may affect the index's value more than others one of the most prominent examples of an index is the dow jones industrial average, which is weighted for price and tracks 30 stocks important in american markets. Therapeutic drug monitoring is the measurement of specific drugs at timed intervals in order to maintain a relatively constant concentration of the medication in the bloodstream monitored drugs tend to have a narrow therapeutic index, a ratio between the toxic and therapeutic doses of medications. Therapeutic index n noun: refers to person, place, thing, quality, etc (toxicity or safety of a drug) índice terapéutico loc nom m locución nominal masculina: unidad léxica estable formada de dos o más palabras que funciona como sustantivo masculino (ojo de buey, agua mala). The inaba text describes the phenomenon of therapeutic index addiction to barbiturates can be critical in terms of lethality as measured by the therapeutic index.
In anticancer therapy, this is the ratio of a dose of the treatment agent that damages normal cells to the dose necessary to produce a determined level of anticancer activity. Narrow therapeutic index (nti) is a very close margin between the concentration in the blood circulation of a drug that is therapeutic and the concentration that is lethal (deadly) pharmacists generally express the therapeutic index as a ratio between the median effective dose (ed50) and the median lethal dose (ld50). National disease and therapeutic index the national disease and therapeutic index (ndti) is a commercial data resource maintained by ims health, in plymouth meeting, pennsylvania. Half maximal effective concentration (ec50) = concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum.